New Prescription EPCS Rules

There are several validation rules set forth by the DEA that must be met when electronically prescribing controlled substances. These rules are as follows:

Schedule II Controlled Substance Prescriptions Rules:

  • All Schedule II electronic prescriptions must be signed by the prescribing clinician using two-factor authentication. This is done using either a mobile two-factor authentication or USB Token two-factor authentication within the application.
  • The prescriber's DEA Number is required.
  • Both the prescriber and pharmacy must be registered with the Controlled Substance service level within the Surescripts directory.
  • No Refills are allowed.
  • To prescribe more than 1 fill, use the Effective Date field to send a prescription valid for a future date in place of a refill.

  • When prescribing Gamma-Hydroxyburic acid/GHB/Xyrem, it is required to add a note for the medical need in the GHB Reason field.

Schedule III-IV Controlled Substance Prescriptions Rules:

  • All Schedule III-IV electronic prescriptions must be signed by the prescribing clinician using two-factor authentication.
  • The prescriber's DEA Number is required.
  • Both the prescriber and pharmacy must be registered with the Controlled Substance service level within the Surescripts directory.
  • A maximum of 5 Refills (6 total fills) can be prescribed.
  • Most electronic prescriptions for buprenorphine also require the prescriber's NADEAN number. Select the NADEAN checkbox to send this with the EPCS prescription.